[Ebook.vg2E] Antifungals From Genomics to Resistance and the Development of Novel Agents
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Infections caused by pathogenic fungi are a significant global problem, a situation exacerbated by the limited availability of good antifungal options. Being eukaryotic organisms, these pathogens are phylogenetically much closer to the human host than bacterial pathogens. This sets serious limits to the range of exploitable fungal-specific drug targets. The advent of 'omics' and other high throughput technologies in recent years has revolutionized the field of antifungal research permitting researchers to quickly identify novel compounds and gain greater insights into drug resistance mechanisms. Researchers can analyze the whole organism's response to any particular condition or compound, thereby providing a deeper understanding of fungal biology and the host-fungus interaction. In this book, a panel of high-profile contributors provides an overview of current antifungal research. Chapters are written from a molecular and genomic perspective and contain speculative models upon which to base future research efforts. Topics include: the molecular mechanisms responsible for antifungal resistance to the classical molecules, azoles, polyenes, and echinocandins * fungal biofilms * fungal-specific biological pathways that constitute potential new targets * strategy to potentiate existing antifungal agents * impact of high throughput screenings of chemical compound collections * modulating the host response * antifungal vaccines * animals models. The book will be an essential reference for everyone with an interest in fungal pathogenesis. It is recommended for all biology and medical libraries. [Subject: Molecular Biology, Genomics, Life Science] DDTWC - Drug Discovery & Therapy World Congress 2017 Drug Discovery & Therapy World Congress 2017 scheduled to be held from 10 th to the 13 th of July 2017 will bring together world's leading scientists in the field ... Antibiotics - Wikipedia Antibiotics also called antibacterials are a type of antimicrobial drug used in the treatment and prevention of bacterial infections. They may either kill or ... Natural product discovery: past present and future ... Microorganisms have provided abundant sources of natural products which have been developed as commercial products for human medicine animal health and plant crop ... Delamanid for Multidrug-Resistant Pulmonary Tuberculosis ... Original Article. Delamanid for Multidrug-Resistant Pulmonary Tuberculosis. Maria Tarcela Gler M.D. Vija Skripconoka M.D. Epifanio Sanchez-Garavito M.D. Heping ... Stony Brook University News & Announcements News & Announcements. rchives: 2004 2005 2006 2007 2008 2009 2010 2011. 2017 News. ICB&DD welcomes Dr. Dongyan Tan Assistant Professor Department of ... Mycology books Caister Academic Press Books published on mycology aimed primarily at research scientists graduate students and professionals. Specialist academic books. A collection of highly acclaimed ... Platforms for antibiotic discovery : Nature Reviews Drug ... Next article. Nature Reviews Drug Discovery Review Advances in the development of new tuberculosis drugs and treatment regimens Sample Files - BioTek Kevin J. Forsberg Sanket Patel Evan Witt Bin Wang Tyler Ellison and Gautam Dantas (2015). "Functional selections of soil metagenomes identify tolerance genes ... Origins and Evolution of Antibiotic Resistance ... FIG. 1. History of antibiotic discovery and concomitant development of antibiotic resistance. The dark ages the preantibiotic era; primordial ... Applications : BioTek Applications. The following resources are available to illustrate product specific capabilities and common applications for BioTek microplate instrumentation.
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